ACE-031

Potential Benefits of Ace-031 Peptide

• According to research, ACE-031 peptide exhibits potential in targeting myostatin/activin A signaling, which could be beneficial for treating diseases associated with muscle loss and metabolic dysfunction. This is primarily due to its ability to bind multiple members of the TGF-β family, thereby demonstrating its effectiveness as a receptor antagonist [1].
• Clinical trials have shown that ACE-031 increases muscle mass and may be effective in treating conditions like cachexia and sarcopenia. The doses used in these studies ranged from 0.02 to 3 mg/kg, and subjects were randomized across six groups [2].
• Studies suggest ACE-031 peptide has shown promise as a treatment for muscular dystrophy [3]. It was awarded orphan status and accelerated review by the FDA for this indication in 2010 [4].
• Research indicates that ACE-031 is not just a selective inhibitor but also blocks BMP8, BMP9, and activins [5], expanding its potential application scope in muscle-related disorders.
• ACE031, a modified version of ACVR2B, has been extensively studied for its potential therapeutic advantages in addressing sarcopenia, a condition characterized by loss of muscle mass and strength associated with aging.[6]. However, its development was halted due to safety concerns.
• Postmenopausal women administered with ACE-031 showed an increase in lean body mass [7]. This research suggests potential use in countering muscle wasting conditions in postmenopausal women.
• ACE-031 peptide significantly increased both type 1 and type 2 muscle fibers, according to a study [8]. This makes it a potential agent in enhancing overall muscle strength and function.
• ACE-2494, an improved version of ACE-031, has been developed and has shown efficacy in stimulating muscle mass and bone growth [9]. This suggests the ongoing evolution and improvement of ACE-031 based treatments.

References

1. https://academic.oup.com/bio medgerontology/article/78/ Supplement_1/32/7026116
2. https://www.tandfonline.com/ doi/abs/ 10.1517/13543781 003724690
3. https://onlinelibrary.wiley. com/doi/full/10.17987/ jcsm-cr.v2i1.37
4. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3819341/
5. https://journals.lww.com/co-neurology/fulltext/2020/10000/ the_elusive_promise_of_ myostatin_inhibition_for.12. aspx
6. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7370765/
7. https://www.sciencedirect.com/ science/article/abs/pii/S875632 8217303459
8. https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC7571243/
9. https://onlinelibrary.wiley. com/doi/full/10.1002/agm2. 12168

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