Mechano Growth Factor (MGF) is an alternative form of IGF-1 (insulin-like growth factor -1), produced by a frame shift in the IGF gene. MGF plays crucial roles in muscle development and repair, making it a focal point in the field of regenerative medicine and athletic performance enhancement.
Upon mechanical overload or damage to muscle tissue, MGF is expressed locally within the damaged muscle fibers and acts to initiate satellite cell proliferation. Satellite cells are quiescent muscle stem cells that can be activated in response to muscle injury or exercise. The activation of these cells by MGF allows for the fusion to existing muscle fibers, promoting hypertrophy and enhancing the body’s ability to repair muscle damage.
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[1] https://www.sciencedirect.com/science/ article/abs/pii/S0047637411000297
[2] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC1571137/
[3] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC10281885/
[4] https://www.sciencedirect.com/science/ article/abs/pii/S0142961214013003
[5] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3167400/
[6] https://www.ncbi.nlm.nih.gov/ pmc/articles/PMC5501366/
[7] https://www.mdpi.com/1422-0067/23/8/4331
[8] https://link.springer.com/ article/10.1007/s11010-013-1689-4
[9] https://pubmed.ncbi.nlm.nih.gov/25129046/
[10] https://pubmed.ncbi.nlm.nih.gov/17984193/
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