Buy Semax Peptide Italy

Buy Semax, a nootropic peptide known for its potential to enhance cognitive performance, protect neurons, and aid in the treatment of conditions like cerebral hypoxia and Alzheimer’s disease.

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Semax Selank Peptide Stack
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Semax Peptide Vial
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Semax Pre-Mixed Pen 2mg Peptide
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Semax Nasal Spray
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Selank Semax Nasal Stack
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Adamax Peptide Vial
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What is Semax?

Semax is a synthetic peptide conisting of 7 amino acids. It is derived from adrenocorticotropic hormone (ACTH) with nootropic and neuroprotective effects. Originally developed in Russia, it has been widely studied for its ability to boost cognitive function, protect neurons, and help regulate the body’s response to stress.

It works by influencing brain-derived neurotrophic factor (BDNF) and interacting with neurotransmitter systems like dopamine and serotonin. This makes it useful for things like stroke recovery, managing neurodegenerative diseases, and improving mental clarity. Its wide range of potential uses in research and therapy makes it an important tool in neuroscience.

The Mechanism of Action of Semax Peptides

Semax, a heptapeptide analog of the adrenocorticotropin fragment, works through a complex mechanism that mainly involves boosting neurotrophic factors and neurotransmitter systems. A key effect of the peptide is increasing brain-derived neurotrophic factor (BDNF), a protein essential for neuron growth, survival, and maintenance. Higher BDNF levels improve synaptic plasticity and neural connections.

The peptide also regulates adrenocorticotropic hormone (ACTH), which helps with stress response and neuroprotection. Additionally, it impacts dopamine and serotonin systems, enhancing mood, motivation, and cognitive function. Its antioxidant properties further protect neurons by reducing oxidative stress and supporting overall brain health. Through these actions, Semax provides strong neuroprotective and cognitive benefits.

Structure of Semax

Sequence:
H-Met-Glu-His-Phe-Pro-Gly-Pro-OH

Molecular Formula:
C37H51N9O10S

Molecular Weight:
813.9 g/mol

PubChem CID: 9811102

What Are The Research Benefits of Semax

Cognitive Enhancement: Research shows it can improve focus, memory, and mental clarity, making it easier to concentrate and learn, even in stressful or fatigued conditions. Animal studies suggest it boosts cognitive function and provides neuroprotective effects when administered intranasally. A single dose (50 µg/kg) increases BDNF protein levels, trkB phosphorylation, and related mRNA expression in the rat hippocampus. Semax-treated rats also perform better in conditioned avoidance tasks, indicating it enhances hippocampal BDNF/trkB activity to support cognitive functions [1].

Neuroprotective and Antiamnesic Effects: Research has demonstrated that Semax exhibits significant neuroprotective and antiamnesic properties, particularly in cases of focal photoinduced ischemia within the prefrontal cortex. When administered intranasally over a six-day period, Semax was shown to reduce the size of cortical infarction significantly. Furthermore, it enhanced the retention and execution of conditioned passive avoidance responses, underscoring its potential in supporting cognitive recovery in neural injury scenarios [2].

Potential for Treating Stroke or Traumatic Brain Injury: It has been studied for use in treating stroke and brain injuries, showing potential to aid recovery and reduce cognitive disorders. Research highlights its angioprotective, antihypoxic, and neurotrophic effects, especially at doses of 100-150 µg/kg. Clinical trials show it may help treat acute ischemic stroke by promoting anti-inflammatory responses and shifting the neuromediatory balance toward anti-inflammatory agents [3].

Mood and Emotional Regulation: Italy Research shows it can improve mood and reduce anxiety by increasing serotonin and dopamine levels. As a peptide analogue of corticotrophin (ACTH), Semax has nootropic effects by modulating brain systems. It raises serotonin metabolite (5-HIAA) levels in the striatum of rodents without affecting dopamine but enhances dopamine release and activity when combined with d-amphetamine. These findings suggest it supports the serotonergic system and boosts dopamine in certain conditions [4].

Reduced Stress and Anxiety: This peptide is believed to help manage stress by regulating cortisol levels, the hormone linked to stress. It may reduce anxiety, particularly in high-stress or performance-based situations. In a Italy study with rats, regular intranasal doses (0.05 mg/kg for 10-14 days) showed anti-anxiety and antidepressant effects, without affecting behavior in calm environments. These benefits are likely connected to the activation of the brain’s serotonin system and higher BDNF expression in the hippocampus [5].

Potential Cardiovascular Benefits: Preliminary research indicates that it might have a role in promoting heart health. Some studies suggest that it could improve blood circulation and protect against ischemic damage, which occurs when there is reduced blood flow to the heart. By enhancing oxygen delivery and reducing oxidative stress, it may offer protective effects for cardiovascular function, though further investigation is required to validate its efficacy and long-term safety in this area [6].

Potential Immunity-Boosting Effects: Emerging studies suggest it may support the immune system by enhancing natural defenses. By promoting white blood cell production and reducing inflammation, it could help the body respond more effectively to infections. Its antioxidant properties may also protect immune cells from damage caused by free radicals. One study examined its effects on immune imbalance caused by social stress in lab animals. Results showed it restored cellular and humoral immunity, improved neutrophil activity, and highlighted its potential as an immune corrector, though further research is needed [7].

Gene Expression: It supports neuron survival, memory, and learning by influencing BDNF and NGF expression in the brain. Italy Studies have shown after a single intranasal dose, gene expression decreases in the hippocampus but increases in the frontal cortex, peaking within 8 hours before returning to baseline. This highlights its rapid, targeted effects on brain function [8].

Buy Semax Italy for research purposes online today!

Buy Semax Selank Peptide Stack

Buy Semax and Selank peptide stack Italy for research laboratory purposes. The stack combines two neuropeptides, Selank 5 mg vial and Semax 2 mg vial, for potential nootropic benefits.

The lyophilized peptide vial stack offers potential synergistic effects to improve mental clarity, focus, and emotional well-being.

Buy Semax Peptide Nasal Spray

Buy Semax nasal spray Italy offers a convenient way to administer the neuropeptide Semax, known for its cognitive and neuroprotective benefits.

Available in 15ml and 30ml bottles, it suits different usage needs. The intranasal administration of Semax ensures quick absorption through the mucous membranes, enhancing focus, learning, and mental performance.

Frequently Asked Questions (FAQs) about Semax

What is the difference between Selank and Semax?

Selank and Semax are synthetic peptides with distinct properties and uses in research. Selank is derived from tuftsin, a sequence of amino acids known for its immunomodulatory effects, and is often researched for its potential to reduce anxiety and improve mood. On the other hand, Semax, derived from adrenocorticotropic hormone (ACTH), is studied for its nootropic properties, including enhancing cognitive function, memory, and learning capacity.

Additionally, their mechanisms of action differ, with Selank primarily influencing the central nervous system through modulation of GABA and serotonin levels, while Semax exerts effects through the melanocortin receptors and neurotrophic regulation. Depending on the research focus, scientists may choose one over the other based on these specific characteristics.

What are the side effects of Semax?

It is generally safe, but some side effects have been noted. These include mild headache, dizziness, irritability, and, in rare cases, changes in mood or sleep patterns. As research is ongoing, side effects may vary based on dosage and individual subject response. Researchers should follow recommended guidelines and exercise caution.

What is a nootropic?

A nootropic is a substance believed to boost cognitive function, including memory, focus, creativity, and mental performance. The term comes from the Greek words “nous” (mind) and “tropein” (to turn), reflecting its positive effect on the brain. Nootropics can include natural compounds, synthetic drugs, or dietary supplements and are often studied for their potential benefits.

Is Semax legal?

It is legal to buy Semax for scientific research in many countries, including the UK and the US. However, it is not approved by the US Food and Drug Administration (FDA) for medical use or human consumption. Researchers and organisations must ensure compliance with local regulations when ordering and handling the peptide for investigational purposes. Always check the specific legal requirements in your region before use.

Buy Semax Italy for research use from Direct Peptides.

Summary of Research Applications

Potential to improve cognitive brain function.
Offers neuroprotective properties.
Treatment of acute cerebral hypoxia.
Helps to enhance mood.
Possible treatment for ADHD.
Reduces symptoms of anxiety and stress.
Potential to improve immune function.

Semax Peptide Quality Assured

Buy Semax peptide with 99% purity from Direct Peptides, designed to support your scientific research on cognition, learning, and memory. Our Semax products are produced to the highest quality standards and undergo rigorous third party testing to ensure their purity and effectiveness.

In addition to our high-quality Semax products, we also provide fast shipping and excellent customer service.

View the HPLC Certificate here.

References For Further Reading

[1] Oleg V Dolotov, Ekaterina A Karpenko, Lyudmila S Inozemtseva, Tamara S Seredenina, et al (2006) Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus – Brain Research, 2006 Oct 30, Volume 1117 (Issue 1), Pages 54-60.

[2] G A Romanova, D N Silachev, F M Shakova, Yu N Kvashennikova, et al (2006) Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex – Bulletin of Experimental Biology & Medicine, 2006 Dec, Volume 142 (Issue 6), Pages 663-6.

[3] N F Miasoedova, V I Skvortsova, E L Nasonov, E Iu Zhuravleva, et al (1999) [Investigation of mechanisms of neuro-protective effect of semax in acute period of ischemic stroke] – Zh Nevrol Psikhiatr Im S S Korsakova, 1999, Volume 99 (Issue 5), Pages 15-9.

[4] Kirill O. Eremin, Vladimir S. Kudrin, Pirjo Saransaari, Simo S. Oja, et al (2005) Semax, An ACTH(4-10) Analogue with Nootropic Properties, Activates Dopaminergic and Serotoninergic Brain Systems in Rodents – Neurochemical Research, December 2005, Volume 30, pages 1493–1500.

[5] D A Vilenskiĭ, N G Levitskaia, L A Andreeva, L Iu Alfeeva, et al (2007) [Effects of chronic Semax administration on exploratory activity and emotional reaction in white rats] – Ross Fiziol Zh Im I M Sechenova, 2007 Jun, Volume 93 (Issue 6), Pages 661-9.

[6] Ekaterina V Medvedeva, Veronika G Dmitrieva, Oksana V Povarova, Svetlana A Limborska, et al (2014) The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis – BMC Genomics, 24 March 2014, volume 15, Article number: 228.

[7] M A Samotrueva, A L Yasenyavskaya, V Kh Murtalieva, O A Bashkina, et al (2019) Experimental Substantiation of Application of Semax as a Modulator of Immune Reaction on the Model of “Social” Stress – Bulletin of Experimental Biology & Medicine, 2019 Apr, Volume 166 (Issue 6), Pages 754-758.

[8] T Iu Agapova, Ia V Agniullin, D N Silachev, M I Shadrina, et al (2008) [Effect of semax on the temporary dynamics of brain-derived neurotrophic factor and nerve growth factor gene expression in the rat hippocampus and frontal cortex] – Mol Gen Mikrobiol Virusol, 2008, (Issue 3), Pages 28-32.

Why Choose Direct Peptides Italy?

Buy Semax today from Direct Peptides Italy, your trusted source for high-quality peptides. We offer a variety of options, including 2mg vials, peptide stacks, nasal sprays (15ml and 30ml), and 2mg pre-mixed pens. Tailored for different research needs, we ensure Italy research professionals have access to the exact formulations they need.

ALL CONTENT AND PRODUCT INFORMATION AVAILABLE ON THIS WEBSITE IS FOR EDUCATIONAL PURPOSES ONLY.

DISCLAIMER: These products are intended solely as a research chemical only. This classification allows for their use only for research development and laboratory studies. The information available on our Italy Direct Peptides website: https://italy.direct-peptides.com is provided for educational purposes only. These products are not for human or animal use or consumption in any manner. Handling of these products should be limited to suitably qualified professionals. They are not to be classified as a drug, food, cosmetic, or medicinal product and must not be mislabelled or used as such.

Buy Semax Peptide Italy

Shop our Full Range of Semax Peptides

What is Semax?