Tesofensine

Potential Benefits of Tesofensine

• Triple Monoamine Reuptake Inhibition: Research suggests Tesofensine acts as a serotonin-noradrenaline-dopamine reuptake inhibitor (SNDRI), thereby increasing the availability of these neurotransmitters in the brain [1].
• Appetite Suppression: Studies indicate the peptide primarily works on the hypothalamus, an important area for appetite regulation. This action enhances satiety signals, leading to reduced food intake [2].
• Efficacy in Weight Loss: A Phase II trial demonstrated significant weight loss in obese patients treated with tesofensine, showing a mean weight loss of 12.8 kg at the highest dose over 24 weeks [3].
• Role in Research: Tesofensine exemplifies a novel approach to obesity treatment by targeting neurotransmitter systems. While it has shown promising results, it’s still not approved for clinical use, indicating its current role is mainly within research settings [3].

References

[1] https://www.sciencedirect.com/ science/article/abs/pii/S0924977X13003003

[2] https://www.researchgate.net/ publication/44608733

[3] https://onlinelibrary.wiley.com/ doi/pdf/10.1038/oby.2011.197

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